Forms a receptor complex with neuropilin-1 and can propagate semaphorin-3A elicited inhibitory signals into cells and neurons.
Function:
Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm
Subunit:
Interacts with NRP1 and NRP2
Subcellular Location:
Cell membrane; Single-pass type I membrane protein
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Belongs to the plexin family.
Contains 4 IPT/TIG domains.
Contains 3 PSI domains.
Contains 1 Sema domain.
SWISS:
Q9HCM2
Gene ID:
91584
Database links:
Entrez Gene: 91584 Human
Entrez Gene: 243743 Mouse
Entrez Gene: 312213 Rat
Omim: 604280 Human
SwissProt: Q9HCM2 Human
SwissProt: Q80UG2 Mouse
Unigene: 511454 Human
Unigene: 48829 Mouse
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