RILPL2 is a 211 amino acid protein that belongs to the RILPL family. RILPL2 does not regulate lysosomal morphology or distribution. RILPL2 shares 32% and 18% amino acid identity with RILPL1 and RILP, respectively. RILPL2 as a novel interacting partner for the actin-based molecular motor MyoVa, and has a novel role for RILPL2 in controlling neuronal morphogenesis. It has been suggested that there is also a novel role for RILPL2 in the regulation of cellular shape and dendritic-spine morphogenesis, probably via the Rac1-Pak pathway. PCR analysis of human tissues detects highest RILPL2 expression in lung, followed by placenta. Lower expression is detected in liver, kidney, pancreas, heart and brain, but no expression is detected in skeletal muscle. The RILPL2 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken and zebrafish, and maps to human chromosome 12q24.31.
Function:
Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance of dendritic spines. May activate RAC1
Subunit:
Interacts (via N-terminus) with MYO5A, the interaction is required for its role in dendrite formation. Interacts with RAC1 (By similarity).
Subcellular Location:
Cytoplasm
Tissue Specificity:
Widely expressed. Expressed at higher level in lung.
Similarity:
Belongs to the RILPL family.
Contains 1 RILP-like domain.
SWISS:
Q969X0
Gene ID:
196383
Database links:
Entrez Gene: 196383 Human
Omim: 614093 Human
SwissProt: Q969X0 Human
Unigene: 488173 Human
|
|
