The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes the theta subunit of the GABA A receptor. The gene is mapped to chromosome Xq28 in a cluster of genes including those that encode the alpha 3 and epsilon subunits of the GABA A receptor. This gene location is also the candidate region of two different neurologic diseases: early-onset parkinsonism (Waisman syndrome) and X-linked mental retardation (MRX3). [provided by RefSeq, Nov 2009]
Function:
The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, theta subunit. GABRQ gene is mapped to chromosome Xq28 in a cluster including the genes encoding the alpha 3 and epsilon subunits of the same receptor. This gene location is also the candidate region of 2 different neurologic diseases: early-onset parkinsonism (Waisman syndrome) and X linked mental retardation (MRX3).
Subunit:
Generally pentameric. This subunit coassembles with alpha-2, beta-1 and gamma-1.
Subcellular Location:
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Similarity:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRQ sub-subfamily.
SWISS:
Q9UN88
Gene ID:
55879
Database links:
Entrez Gene: 55879 Human
Entrez Gene: 57249 Mouse
Entrez Gene: 65187 Rat
Omim: 300349 Human
SwissProt: Q9UN88 Human
SwissProt: A2AEH2 Mouse
SwissProt: Q0VEX8 Mouse
SwissProt: Q9JLF1 Mouse
SwissProt: Q91ZM7 Rat
Unigene: 283081 Human
Unigene: 81067 Rat
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