Associates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements.
Function:
Associates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements.
Subunit:
Homodimer. Forms a complex with GABBR1 and KIF5B/kinesin-1. Interacts with JAK1 and TYK2.
Subcellular Location:
Cytoplasm > cytoskeleton. Membrane. Colocalizes with the microtubule network. Localizes to the cell body and neurites of hippocampal neurons where it accumulates in granules. Localizes to the tail and to a lower extent to the head of sperm cells.
Tissue Specificity:
Predominantly expressed in neural tissues and lymphoid cells (at protein level). Isoform 2, isoform 3 and isoform 4 are specifically expressed in brain and retina. Isoform 1 and isoform 5 are also detected in liver, lung and skeletal muscle. Also detected in testis and to a lower extent spleen and intestine.
Similarity:
Belongs to the JAKMIP family.
SWISS:
Q96N16
Gene ID:
152789
Database links:
Entrez Gene: 152789 Human
Entrez Gene: 76071 Mouse
Entrez Gene: 305434 Rat
Omim: 611195 Human
SwissProt: Q96N16 Human
SwissProt: Q8BVL9 Mouse
SwissProt: Q3SWS9 Rat
Unigene: 479066 Human
Unigene: 85280 Mouse
Unigene: 18970 Rat
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