Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis.
Function:
Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis.
Subunit:
Interacts with AP1G1. Interacts with NOTCH1.
Subcellular Location:
Cell membrane. Present on the membrane of dendrites and cell bodies but excluded from axonal membrane. Also found in early endosomes in the somatodendritic region.
Tissue Specificity:
Expressed in brain, spinal cord and adrenal gland.
Similarity:
Contains 10 EGF-like domains.
Contains 1 follistatin-like domain.
SWISS:
Q8NFT8
Gene ID:
92737
Database links:
Entrez Gene: 92737 Human
Entrez Gene: 227325 Mouse
Entrez Gene: 316573 Rat
Omim: 607299 Human
SwissProt: Q8NFT8 Human
SwissProt: Q8JZM4 Mouse
Unigene: 234074 Human
Unigene: 292560 Mouse
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