G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR18 is a 331 amino acid multi-pass membrane protein that belongs to the G-protein coupled receptor family. Expressed abundantly in spleen and testis, GPR18 functions as a receptor for N-arachidonyl glycine and is thought to contribute to the regulation of the immune system. GPR18 activity is mediated by G proteins that specifically inhibit adenylyl cyclase.
Function:
G protein coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. GPCR GPR18 is a member of this family and has been reported to be expressed at high levels in testis and spleen and at lower levels in other tissues associated with endocrine and immunologic/hematologic functions. It is thought to be a receptor for N arachidonyl glycine. It may contribute to regulation of the immune system.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Most abundant in testis and spleen. Highly expressed in CD4 and CD8-positive T-cells as well as CD19-positive B-cells.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
SWISS:
Q14330
Gene ID:
2841
Database links:
Entrez Gene: 2841 Human
Entrez Gene: 110168 Mouse
Entrez Gene: 679957 Rat
Omim: 602042 Human
SwissProt: Q14330 Human
SwissProt: Q8K1Z6 Mouse
SwissProt: A1A5S3 Rat
Unigene: 741589 Human
Unigene: 37405 Mouse
Unigene: 205907 Rat
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