Voltage-gated K+ channels in the plasma membrane are important regulators of electrical signaling, controlling the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. KCNT2 is a 1,135 amino acid multi-pass transmembrane protein belonging to the potassium channel family (calcium-activated subfamily) of proteins. KCNT2 produces rapidly activating outward rectifier potassium currents in reponse to high intracellular sodium and chloride levels. Its channel activity is inhibited by ATP, inhalation anesthetics, such as isoflourane, and upon stimulation of G-protein coupled receptors, such as mAChR M1 and GluR-1. There are four isoforms of KCNT2 that are produced as a result of alternative splicing events.
Function:
KCNT2 belongs to the potassium channel family, calcium-activated subfamily and contains one RCK N-terminal domain. KCNT2 is an outward rectifying potassium channel and produces rapidly activating outward rectifier K(+) currents. It is activated by high intracellular sodium and chloride levels. Channel activity is inhibited by ATP and by inhalation anesthetics, such as isoflurane. KCNT2 is inhibited upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. There are four named isoforms.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Post-translational modifications:
Phosphorylated by protein kinase C. Phosphorylation of the SLCterminal domain inhibits channel activity.
Similarity:
Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa4.2/KCNT2 sub-subfamily.
Contains 1 RCK N-terminal domain.
SWISS:
Q6UVM3
Gene ID:
343450
Database links:
Entrez Gene: 343450 Human
Entrez Gene: 48776 Mouse
Entrez Gene: 304827 Rat
Omim: 610044 Human
SwissProt: Q6UVM3 Human
SwissProt: Q6UVM4 Rat
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