The transcpritional repressor ZBRK1, also designated zinc finger and BRCA1-interacting protein with a KRAB domain 1 or zinc finger protein 350, belongs to the Krüppel C2H2-type zinc-finger protein family of proteins. ZBRK1 localizes mainly to the nucleus and may be associated with the nuclear matrix. It is a widely expressed protein that binds to BRCA1. ZBRK1 plays an important role in transcriptional regulation. Likely targets of gene regulation are DNA damage response genes, which effect the survival and growth control of cells. ZBRK1 contains an N-terminal KRAB domain, a SLCterminal BRCA1-binding region and eight central zinc-fingers.
Function:
Transcriptional repressor. Binds to a specific sequence, 5'-GGGxxxCAGxxxTTT-3', within GADD45 intron 3.
Subunit:
Interacts with BRCA1. Interacts with RNF11.
Subcellular Location:
Nucleus matrix. Associated with the nuclear matrix.
Tissue Specificity:
Widely expressed.
Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 8 C2H2-type zinc fingers.
Contains 1 KRAB domain.
SWISS:
Q9GZX5
Gene ID:
59348
Database links:
Entrez Gene: 59348 Human
Entrez Gene: 234358 Mouse
Entrez Gene: 100158232 Rat
Omim: 605422 Human
SwissProt: Q9GZX5 Human
Unigene: 407694 Human
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