This orphan B G-protein coupled receptor could be involved in a signal transduction pathway controlling epidymal function and male fertility: it has been reported in the epididymis. ESTs have been isolated from embryo, kidney, placenta, skeletal muscle and testis libraries.
Function:
Could be involved in a signal transduction pathway controlling epididymal function and male fertility.
Subunit:
Forms a heterodimer, consisting of a large extracellular region linked to a seven-transmembrane moiety (Probable).
Subcellular Location:
Cell membrane; Multi pass membrane protein.
Tissue Specificity:
Epididymis specific. Both subunits were associated with apical membranes of efferent ductule and proximal epididymal duct epithelia.
Post-translational modifications:
Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit (Potential).
Similarity:
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Contains 1 GPS domain.
SWISS:
Q8IZP9
Gene ID:
10149
Database links:
Entrez Gene: 100299135 Cow
Entrez Gene: 491763 Dog
Entrez Gene: 10149 Human
Omim: 602657 Human
SwissProt: Q8IZP9 Human
Unigene: 421137 Human
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