Hedgehog (Hh) signaling proteins are critical for growth and tissue patterning during development. Patched (Ptc), a putative 12 transmembrane receptor, binds to Sonic hedgehog and is suspected to be a negative regulator of Hh signaling. A family member of patched, designated patched 2, has been found to be co-expressed with Sonic hedgehog. Smoothened (Smo), a seven transmembrane receptor, is complexed with patched in many tissues and is believed to be an essential component in the Hh signaling pathway. Hhip (hedgehog-interacting protein) is able to bind to and may be a transcriptional target of all Hh proteins. Binding of Hhip to Hh proteins attenuates hedgehog signaling.
Function:
Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family.
Subunit:
Interacts with all three hedgehog family members, SHH, IHH and DHH.
Subcellular Location:
Cytoplasm and Cell membrane. Secreted. The last 22 SLCterminal amino acids may participate in cell membrane attachment.
Tissue Specificity:
Widely expressed in fetal and adult tissues. Highest expression in adult heart, liver and pancreas, and in fetal kidney.
Similarity:
Belongs to the HHIP family.
Contains 2 EGF-like domains.
SWISS:
Q96QV1
Gene ID:
64399
Database links:
Entrez Gene: 540830 Cow
Entrez Gene: 64399 Human
Entrez Gene: 15245 Mouse
Omim: 606178 Human
SwissProt: Q96QV1 Human
SwissProt: Q7TN16 Mouse
Unigene: 507991 Human
Unigene: 254493 Mouse
|
|
