SCUBE3 is a novel secreted 993 amino acid cell-surface osteoblast protein that plays an important role in bone cell biology. While highly expressed in osteoblasts, SCUBE3 expression is unobservable or very low in non-bone tissues. SCUBE3 forms homo-oligomers and hetero-oligomers with SCUBE1, and may undergo SLCterminal proteolytic cleavage or become N-glycosylated following translation. Two SCUBE3 isoforms exist as a result of alternative splicing events. SCUBE3 contains one CUB domain and nine EGF-like domains, and is encoded by a gene which maps to human chromosome 6p21.31, a region associated with a rare form of metabolic bone disease known as Paget's disease. Chromosome 6 contains 170 million base pairs and comprises nearly 6% of the human genome.
Function:
Binds to TGFBR2 and activates TGFB signaling. In lungcancer cells, could serve as an endogenous autocrine and paracrineligand of TGFBR2, which could regulate TGFBR2 signaling and hencemodulate epithelial-mesenchymal transition and cancer progression.
Subunit:
Forms homooligomers and heterooligomers with SCUBE1.Interacts with TGFBR2 through the CUB domain; this interaction doesnot affect TGFB1-binding to TGFBR2.
Subcellular Location:
Secreted. Cell surface.
Tissue Specificity:
Highly expressed in osteoblasts. Expression is low or absent in non-bone tissues.
Post-translational modifications:
N-glycosylated.
May undergo proteolytic cleavage in the SLCterminal region.
Similarity:
Contains 1 CUB domain.
Contains 9 EGF-like domains.
SWISS:
Q8IX30
Gene ID:
222663
Database links:
Entrez Gene: 222663 Human
Entrez Gene: 268935 Mouse
Omim: 614708 Human
SwissProt: Q8IX30 Human
SwissProt: Q66PY1 Mouse
Unigene: 12923 Human
Unigene: 258491 Mouse
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