Rabbit Anti-SCUBE2 antibody

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4932442O19Rik; Cegb1; Cegf1; CEGP1; Cegp1 protein; CUB domain and EGF-like repeat containing 1; FLJ16792; FLJ35234; ICRFP703B1614Q5.1; MGC133057; Protein CEGP1; RGD1563998; SCUB2_HUMAN; Scube2; Signal peptide, CUB and EGF-like domain-containing protein 2;

Cat:

SL12318R

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Dog,Horse,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from Human SCUBE2:881-999/999

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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SCUBE2 is a 999 amino acid protein that is ubiquitously expressed in adult tissues and belongs to the evolutionarily conserved SCUBE protein family. Containing a CUB domain and nine EGF-like domains, SCUBE2 manifests as a secreted surface-anchored glycoprotein when overexpressed and is considered a novel component of the HH (Hedgehog) signal. The HH signal plays a pivotal role in induction of ventral neuronal and muscle cell types around the midline during vertebrate development. It is suggested that SCUBE2 expression is important in breast cancer progression and may serve as a useful prognostic marker. SCUBE2 forms homo-oligomers and hetero-oligomers with SCUBE1 and SCUBE3. Expressed as three isoforms produced by alternative splicing events, SCUBE2 is encoded by a gene located on human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome.

Subunit:
Forms homooligomers and heterooligomers with SCUBE1 and SCUBE3 (By similarity).

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed in a broad spectrum of adult tissues.

Similarity:
Contains 1 CUB domain.
Contains 9 EGF-like domains.

SWISS:
Q9NQ36

Gene ID:
57758

Database links:

Entrez Gene: 57758 Human

Entrez Gene: 56788 Mouse

Omim: 611747 Human

SwissProt: Q9NQ36 Human

SwissProt: Q9JJS0 Mouse

Unigene: 523468 Human

Unigene: 40447 Mouse

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