CFDP1 is a 299 amino acid protein that is involved in embryogenesis and normal cell function. When treated with CFDP1 peptide, mouse molar teeth increase in size, whereas treating cells with antibodies against CFDP1 shows an increase in the number of apoptotic cells and gradual tooth disintegration. CFDP1 is highly expressed in developing mouse teeth and is expressed at lower levels in liver, lung and heart. The gene encoding CFDP1 maps to human chromsome 16, in a region that has been associated with inherited craniofacial diseases, such as fanconi anemia type A. There are two isoforms of CFDP1 that are produced as a result of alternative splicing events.
Function:
May play a role during embryogenesis (By similarity).
Tissue Specificity:
Ubiquitous.
Post-translational modifications:
Phosphorylated by CK2 (casein kinase II) in vitro.
Similarity:
Contains 1 BCNT-C domain.
SWISS:
Q9UEE9
Gene ID:
10428
Database links:
Entrez Gene: 10428 Human
Entrez Gene: 23837 Mouse
Entrez Gene: 292027 Rat
Omim: 608108 Human
SwissProt: Q8HXY9 Cow
SwissProt: Q9UEE9 Human
SwissProt: O88271 Mouse
SwissProt: Q75UQ2 Rat
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