Members of the SPEN (Split-end) family of proteins, including RBM15, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]).[supplied by OMIM, Feb 2009]
Function:
Rbm15 plays an important role in hematopoietic development, with pleiotropic effects in the stem cell, lymphoid, and myeloid compartments.
Subunit:
Interacts with Epstein-Barr virus BSFL2/BMLF1.
Subcellular Location:
Nuclear.
DISEASE:
Note=A chromosomal aberration involving RBM15 may be a cause of acute megakaryoblastic leukemia. Translocation t(1;22)(p13;q13) with MKL1. Although both reciprocal fusion transcripts are detected in acute megakaryoblastic leukemia (AMKL, FAB-M7), the RBM15-MKL1 chimeric protein has all the putative functional domains encoded by each gene and is the candidate oncogene.
Similarity:
Belongs to the RRM Spen family.
Contains 3 RRM (RNA recognition motif) domains.
Contains 1 SPOC domain.
SWISS:
Q96T37
Gene ID:
64783
Database links:
Entrez Gene: 64783 Human
Omim: 606077 Human
SwissProt: Q96T37 Human
Unigene: 435947 Human
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