FJX1 is a 437 amino acid protein that belongs to the FJX1/FJ family. FJX1 is highly conserved in vertebrates and is expressed in the peripheral nervous system, epithelial cells of multiple organs and during limb development. FJX1 is processed and secreted as a presumptive ligand and may act as an inhibitor of dendrite extension and branching. In Drosophila, FJX1 is important for growth and differentiation of legs and wings, and for proper development of the eyes. FAT4, an essential gene that has a key role in vertebrate PCP (planar cell polarity), represses FJX1 expression which may lead to cystic diseases in humans.
Function:
FJX1 is the human ortholog of mouse and Drosophila four-jointed gene product. The Drosophila protein is important for growth and differentiation of legs and wings, and for proper development of the eyes. The exact function of this gene in humans is not known.
Subcellular Location:
Secreted
Post-translational modifications:
Glycosylated (By similarity).
Undergoes proteolytic cleavage (By similarity).
Similarity:
Belongs to the FJX1/FJ family.
SWISS:
Q86VR8
Gene ID:
24147
Database links:
Entrez Gene: 24147 Human
Omim: 612206 Human
SwissProt: Q86VR8 Human
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