This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C, 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Function:
Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.
Subunit:
Interacts with EIF4B, IMP8, PRMT5 and TNRC6B. Interacts with APOBEC3F, APOBEC3G and APOBEC3H.
Subcellular Location:
Cytoplasm.
Similarity:
Belongs to the argonaute family. Ago subfamily.
Contains 1 PAZ domain.
Contains 1 Piwi domain.
SWISS:
Q9H9G7
Gene ID:
192669
Database links:
Entrez Gene: 192669 Human
Entrez Gene: 214150 Mouse
Entrez Gene: 313593 Rat
Omim: 607355 Human
SwissProt: Q9H9G7 Human
SwissProt: Q8CJF9 Mouse
Unigene: 657659 Human
Unigene: 88915 Mouse
Unigene: 482388 Mouse
Unigene: 483093 Mouse
Unigene: 92025 Rat
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