This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic containing PAZ and PIWI domains, and it may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of closely related family members including argonaute 3, and eukaryotic translation initiation factor 2C, 1. [provided by RefSeq, Jul 2008]
Function:
Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV).
Subunit:
Interacts with EIF4B, IMP8, PRMT5, TNRC6A and TNRC6B.
Subcellular Location:
Cytoplasm.
Similarity:
Belongs to the argonaute family. Ago subfamily.
Contains 1 PAZ domain.
Contains 1 Piwi domain.Cellular localization.
SWISS:
Q9HCK5
Gene ID:
192670
Database links:
Entrez Gene: 192670 Human
Entrez Gene: 76850 Mouse
Entrez Gene: 298533 Rat
Omim: 607356 Human
SwissProt: Q9HCK5 Human
SwissProt: Q8CJF8 Mouse
Unigene: 471492 Human
Unigene: 86705 Mouse
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