Sulfatases (EC 3.1.5.6), such as ARSI, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008].
Function:
Sulfatases such as ARSI, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules
Subcellular Location:
Endoplasmic reticulum and Secreted
Tissue Specificity:
Expressed in placenta, in embryonic stem cells, fetal eyes and lens.
Post-translational modifications:
The oxidation of Cys-93 residue to 3-oxoalanine (also known as C(alpha)-formylglycine) by SUMF1/Sulfatase-modifying factor 1, seems critical for catalytic activity.
Similarity:
Belongs to the sulfatase family.
SWISS:
Q5FYB1
Gene ID:
340075
Database links:
Entrez Gene: 340075 Human
Omim: 610009 Human
SwissProt: Q5FYB1 Human
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