Aurora related kinase-1 (ARK-1) is a centrosome-associated serine/threonine kinase that regulates centrosome separation, bipolar spindle assembly and chromosome segregation during mitosis. Bora (protein aurora borealis) is a 559 amino acid protein that activates ARK-1. Bora is localized to the nucleus until mitosis is initiated, when it then translocates to the cytoplasm. This translocation is dependent on activated Cdc2, which releases Bora to bind and activate ARK-1 in the cytoplasm. Plk (polo-like kinase) interacts with Bora to control the accessibility of its activation loop for phosphorylation and activation on its N-terminus by ARK-1. It is through this mechanism that Bora and ARK-1 control cellular mitotic entry. Downregulation of the gene encoding Bora results in multipolar spindles in mitosis, a phenomenon that is also observed when ARK-1 function is blocked.
Function:
Required for the activation of Aurora-A (AURKA/STK6) at the onset of mitosis.
Subunit:
Interacts with AURKA.
Post-translational modifications:
Phosphorylated by AURKA/STK6.
Similarity:
Belongs to the BORA family.
SWISS:
Q6PGQ7
Gene ID:
79866
Database links:
Entrez Gene: 79866 Human
Entrez Gene: 77744 Mouse
Entrez Gene: 306102 Rat
Omim: 610510 Human
SwissProt: Q6PGQ7 Human
SwissProt: Q8BS90 Mouse
SwissProt: Q5M864 Rat
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