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Rabbit Anti-BTN2A1 + BTN2A2 antibody
Butyrophilin is a glycoprotein that is specifically expressed on the apical surface of mammary epithelial cells during lactation and becomes incorporated as an integral protein into the membrane of the milk fat globule during the budding and secretion of fat droplets into milk. BTN2A1 (butyrophilin subfamily 2 member A1), also known as BTF1, is a 527 amino acid single-pass type I membrane B box protein that plays a role in fatty-acid, sterol and lipid metabolism. A member of the immunoglobulin superfamily and BTN/MOG family, BTN2A1 exists as three alternatively spliced isoforms found at high levels in brain, muscle, spleen, pancreas, bone marrow and small intestine. BTN2A1 is expressed at moderate levels in kidney, liver and lung, and is encoded by a gene that maps to human chromosome 6p22.1.
Subcellular Location:
Membrane; Single-pass type I membrane protein (By similarity).
Tissue Specificity:
Highly expressed in brain, bone marrow, small intestine, muscle, spleen and pancreas. Moderate expression was seen in lung, liver and kidney.
Similarity:
Belongs to the immunoglobulin superfamily. BTN/MOG family.
Contains 1 B30.2/SPRY domain.
Contains 1 Ig-like SLVtype (immunoglobulin-like) domain.
SWISS:
Q7KYR7
Gene ID:
11120
Database links:
Entrez Gene: 11120 Human
Omim: 613590 Human
SwissProt: Q7KYR7 Human
Unigene: 159028 Human
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