TORC3 is a 619 amino acid protein that localizes to both the cytoplasm and the nucleus and belongs to the TORC family. Expressed in lung tissue and B and T lymphocytes, as well as in colon, brain, ovary, kidney, prostate, colon and heart, TORC3 functions as a transcriptional coactivator for CREB-1, thereby regulating the expression of CREB-activated genes, and is also thought to activate the SIK/TORC signaling pathway. TORC3 exists as multiple alternatively spliced isoforms and, in addition to its role in transcriptional activation, is thought to induce mitochondrial biogenesis, specifically in muscle cells.
Function:
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLSLV1) long terminal repeats (LTR).
Subunit:
Binding, as a tetramer, through its N-terminal region,with the bZIP domain of CREB1 enhances recruitment of TAF4 to thepromoter. 'Arg-314' in the bZIP domain of CREB1 is essential forthis interaction (By similarity). Interaction with HTLSLV1 TAXenhances its transcriptional activity. Interacts, via theN-terminal with the ankyrin repeats of BCL3, to form a complex withCREB1 on CRE and TxRE responsive elements and represses HTLSLV1LTR-mediated transcription.
Subcellular Location:
Nucleus. Cytoplasm. Appears to be mainly nuclear.
Tissue Specificity:
Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach.
Similarity:
Belongs to the TORC family.
SWISS:
Q6UUV7
Gene ID:
64784
Database links:
Entrez Gene: 64784 Human
Entrez Gene: 70461 Mouse
Entrez Gene: 365297 Rat
Omim: 608986 Human
SwissProt: Q6UUV7 Human
SwissProt: Q91X84 Mouse
Unigene: 567572 Human
Unigene: 392175 Mouse
|
|
