DTYMK is a 212 amino acid protein that belongs to the thymidylate kinase family and is involved in pyrimidine metabolism. Specifically, DTYMK catalyzes the ATP-dependent conversion of dTMP (deoxythymidine monophosphate) to dTDP (deoxythymidine diphosphate), which then functions as one of the four nucleotides in DNA. Via its role in the catalytic creation of dTDP, DTYMK plays an important role in the pathway of DNA synthesis and is thought to be involved in cell cycle progression and cell growth. DTYMK expression levels peak during the S phase (synthesis phase) of the cell cycle, further supporting the role of DTYMK in DNA synthesis.
Function:
Catalyzes the conversion of dTMP to dTDP.
Similarity:
Belongs to the thymidylate kinase family.
SWISS:
P23919
Gene ID:
1841
Database links:
Entrez Gene: 1841 Human
Entrez Gene: 21915 Mouse
Omim: 188345 Human
SwissProt: P23919 Human
SwissProt: P97930 Mouse
Unigene: 471873 Human
Unigene: 250332 Mouse
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