This gene encodes a member of the epidermal growth factor(EGF) repeat superfamily. Members of this superfamily arecharacterized by the presence of EGF-like repeats and are ofteninvolved in the regulation of cell cycle, proliferation, anddevelopmental processes. The gene product contains a signalpeptide, suggesting that it is secreted; an EGF repeat regionconsisting of 4 complete EGF-like repeats and 1 partial EGF-likerepeat, 3 of which have a calcium-binding consensus sequence; anarg-gly-asp integrin association motif; and a MAM domain, which isbelieved to have an adhesive function. This gene is expressed earlyduring development, and its expression has been detected in lungand meningioma tumors. [provided by RefSeq, Jul 2008].
Function:
May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly.
Subcellular Location:
Secreted, extracellular space, extracellularmatrix, basement membrane (By similarity).
Similarity:
Belongs to the nephronectin family.
Contains 5 EGF-like domains.
Contains 1 MAM domain.
SWISS:
Q8IUX8
Gene ID:
25975
Database links:
Entrez Gene: 25975 Human
Entrez Gene: 54156 Mouse
Entrez Gene: 317470 Rat
Omim: 300239 Human
SwissProt: Q8IUX8 Human
SwissProt: Q9JJZ5 Mouse
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