EMSY binds BRCA2 within a region (exon 3) deleted in cancer. EMSY is capable of silencing the activation potential of BRCA2 exon 3, associates with chromatin regulators HP1 and BS69, and localizes to sites of repair following DNA damage. Its levels are amplified in breast and ovarian cancer.
Function:
Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2.
Subunit:
Homodimer. Interacts with the transactivation domain of BRCA2. Interacts with the chromoshadow domain of CBX1 and with ZMYND11. Does not interact with CBX3 or CBX5.
Subcellular Location:
Nuclear. Localizes to DNA damage markers in irradiated cells; suggesting that it participates in the DNA repair process.
Similarity:
Contains 1 ENT (EMSY N-terminal) domain.
SWISS:
Q7Z589
Gene ID:
56946
Database links:
Entrez Gene: 56946 Human
Entrez Gene: 233545 Mouse
Omim: 608574 Human
SwissProt: Q7Z589 Human
SwissProt: Q8BMB0 Mouse
Unigene: 352588 Human
Unigene: 387819 Mouse
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