Cycling proteins play important roles in the organization and function of the early secretory pathway by participating in membrane traffic and selective transport of cargo between the endoplasmic reticulum (ER), the intermediate compartment (ERGIC), and the Golgi. A family of membrane bound, ubiquitous proteins involved in the selective transport of newly synthesized glycoproteins from the ER to the ERGIC include VIP36, ERGISLC53, ERGISLC1, ERGISLC2 and ERGISLC3. ERGISLC1, also designated ERGIC32, is thought to modulate the activity of a complex formed by ERGISLC2, also designated Erv41, and ERGISLC3, also designated Erv46. ERGISLC2 and ERGISLC3 are both mammalian homologs of yeast proteins abundant in COPII-coated vesicles and localize to the Cis-face of the Golgi apparatus.
Function:
Possible role in transport between endoplasmic reticulum and Golgi.
Subunit:
Interacts with ERGIC1/ERGIC32.
Subcellular Location:
Endoplasmic reticulum-Golgi intermediate compartment membrane. Golgi apparatus > cis-Golgi network membrane. Endoplasmic reticulum membrane. Cycles between the endoplasmic reticulum and the Golgi.
Similarity:
Belongs to the ERGIC family.
SWISS:
Q9Y282
Gene ID:
51614
Database links:
Entrez Gene: 51614 Human
Entrez Gene: 66366 Mouse
Entrez Gene: 296306 Rat
SwissProt: Q9Y282 Human
SwissProt: Q9CQE7 Mouse
Unigene: 472558 Human
Unigene: 141276 Mouse
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