Ethanolamine kinase 2, also known as EKI2, ETNK2 or HMFT1716, is a 386 amino acid protein that belongs to the choline/ethanolamine kinase family. Via the cytidine diphosphate (CDP) ethanolamine pathway, Ethanolamine kinase 2 catalyses the initial step of phosphatidylethanolamine (PtdEtn) biosynthesis. Ethanolamine kinase 2 is expressed in kidney, liver, testis, ovary and prostate, and is highly specific for ethanolamine phosphorylation. Upregulated during testis development, Ethanolamine kinase 2 may play an essential role in regulating placental hemostasis. Existing as three alternatively spliced isoforms, the gene encoding Ethanolamine kinase 2 maps to human and mouse chromosome 1. Human chromosome 1 spans 260 million base pairs, contains over 3,000 genes, comprises nearly 8% of the human genome and houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome.
Function:
Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity.
Subcellular Location:
Belongs to the choline/ethanolamine kinase family.
Tissue Specificity:
Expressed in kidney, liver, ovary, testis and prostate.
Similarity:
Belongs to the choline/ethanolamine kinase family.
SWISS:
Q9NVF9
Gene ID:
64123
Database links:
Entrez Gene: 55224 Human
Entrez Gene: 214253 Mouse
Entrez Gene: 100622861 Pig
Entrez Gene: 72843 Rat
Omim: 609859 Human
SwissProt: Q9NVF9 Human
SwissProt: A7MCT6 Mouse
SwissProt: D3ZRW8 Rat
Unigene: 497469 Human
Unigene: 52111 Mouse
Unigene: 65516 Rat
|
|
