Activation of FUSE, the far-upstream element, is required for the proper ex-pression of the mammalian gene c-Myc in undifferentiated cells. The binding of FBP (FUSE-binding protein or Far upstream element binding protein) to FUSE is necessary for c-Myc expression, indicating that FBP functions as a growth-dependent regulator of c-Myc expression. Isolated from proliferating HL60 cells, FBP, FBP2, and FBP3 comprise a family of single-stranded DNA-binding proteins that specifically bind to FUSE elements. The FBP transcription factors share a conserved central DNA-binding domain and show significant homology in their carboxyl-terminal activation domains. Expression of FBP is detected in undifferentiated cells and is substantially decreased following cellular differentiation.
Function:
May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression.
Subcellular Location:
Nucleus.
Tissue Specificity:
Detected in a number of cell lines.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Contains 4 KH domains.
SWISS:
Q96I24
Gene ID:
8939
Database links:
Entrez Gene: 8939 Human
Entrez Gene: 64267 Mouse
Entrez Gene: 362106 Rat
Omim: 603536 Human
SwissProt: Q96I24 Human
Unigene: 673029 Human
Unigene: 98751 Human
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