Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS).
Function:
Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS).
Subcellular Location:
Endoplasmic reticulum membrane.
Tissue Specificity:
Expressed in all tissues examined. Highest expression in placenta. High expression in lung, kidney, stomach and small intestine, low expression in heart, spleen and skeletal muscle. Weakly expressed in normal hematopoietic tissues. Higher expression in some T-cell malignancies and PHA-stimulated lymphocytes.
DISEASE:
Note=A chromosomal aberration involving KDSR is a cause of follicular lymphoma; also known as type II chronic lymphatic leukemia. Translocation t(2;18)(p11;q21) with a Ig J kappa chain region.
Similarity:
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
SWISS:
Q06136
Gene ID:
2531
Database links:
Entrez Gene: 505558 Cow
Entrez Gene: 2531 Human
Entrez Gene: 70750 Mouse
Entrez Gene: 72833 Rat
Omim: 13688 Human
SwissProt: Q2KIJ5 Cow
SwissProt: Q06136 Human
SwissProt: Q6GV12 Mouse
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