This reference sequence was derived from multiple replicate ESTs and validated by similar human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the SLCterminus on the cytoplasmic side of the membrane. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. This gene product, FXYD7, is novel and has not been characterized as a protein. [RefSeq curation by Kathleen J. Sweadner, Ph.D., [email protected]., Dec 2000].
Subcellular Location:
Membrane; Single-pass membrane protein (Potential).
Similarity:
Belongs to the FXYD family.
SWISS:
P58549
Gene ID:
53822
Database links:
Entrez Gene: 53822 Human
Entrez Gene: 57780 Mouse
Entrez Gene: 63848 Rat
Omim: 606684 Human
SwissProt: P58549 Human
SwissProt: P59648 Mouse
SwissProt: P59649 Rat
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