Purines are critical for energy metabolism, cell signaling and cell reproduction and also function as precursors for coenzymes, energy transfer molecules, regulatory factors and proteins involved in RNA and DNA synthesis. GART (GAR transformylase), also referred to as AIRS, GARS, PAIS, PGFT, PRGS or GARTF, is 1,010 amino acids in length and is a key folate-dependent trifunctional enzyme with phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase and AICAR (phosphoribosylaminoimidazole synthetase) activity required for de novo purine biosynthesis. Cancer cells require considerable amounts of purines to sustain their accelerated growth and GART is, therefore, a target for cancer chemotherapy. GART is highly conserved in vertebrates. Two isoforms of GART are expressed due to alternative splicing events.
Similarity:
In the N-terminal section; belongs to the GARS family.
In the central section; belongs to the AIR synthase family.
In the SLCterminal section; belongs to the GART family.
Contains 1 ATP-grasp domain.
SWISS:
P22102
Gene ID:
2618
Database links:
Entrez Gene: 2618 Human
Entrez Gene: 14450 Mouse
Entrez Gene: 288259 Rat
Omim: 13888 Human
SwissProt: P22102 Human
SwissProt: Q64737 Mouse
Unigene: 473648 Human
Unigene: 4505 Mouse
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