Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2.
Function:
Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2.
Subunit:
Homodimer. Interacts (via GRIP domain) with RAB6A (preferentially in its GTP-bound form). May interact (RAB6A-dependent) with ARL1; according to PubMed:19703403, RAB6A and ARL1 are not involved in GCC2 Golgi localization as proposed by PubMed:18243103. Interacts (probably via GRIP domain) with RAB9A (preferentially in its GTP-bound form). Interacts with CLASP1 and CLASP2; recruits both proteins to membranes of the TGN. Interacts with STX16. [INTERACTION] Self; NbExp=2; IntAct=EBI-1645335, EBI-1645335; P20340:RAB6A; NbExp=4; IntAct=EBI-1645335, EBI-1052826.
Subcellular Location:
Cytoplasm. Golgi apparatus; trans-Golgi network membrane.
Tissue Specificity:
Ubiquitous.
Similarity:
Contains 1 GRIP domain.
SWISS:
Q8IWJ2
Gene ID:
9648
Database links:
Entrez Gene: 9648 Human
Entrez Gene: 70297 Mouse
Omim: 612711 Human
SwissProt: Q8IWJ2 Human
SwissProt: Q8CHG3 Mouse
Unigene: 436505 Human
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