The gamma-Tubulin complex is composed of gamma Tubulin and the gamma-Tubulin complex-associated proteins GCP2, GCP3, GCP4, GCP5 and GCP6, all of which are essential components of microtubule organizing centers. gamma-Tubulin complex components are localized to both the centrosome, where they are involved in microtubule nucleation, and to the cytoplasm, where they exist as soluble complexes that can be recruited to the centrosome as needed. Although the GCP proteins are related, they have distinct roles which contribute to the proper function of the gamma-Tubulin complex. GCP4 (gamma-tubulin complex component 4), also known as TUBGCP4, is a ubiquitously expressed 667 amino acid member of the gamma-Tubulin complex that localizes to the metaphase spindle during mitosis. In response to proteosome inhibition, GCP4 exhibits increased accumulation at the pericentiolar material where it participates in microtubule organization and nucleation.
Function:
GCP4 is a component of the gamma-tubulin complex which is necessary for microtubule nucleation at the centrosome. GCP4 shows sequence identity with the SLCterminal regions of human centrosomal proteins 103p (TUBGCP2) and 104p (TUBGCP3).
Subunit:
Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6. Interacts with NINL.
Subcellular Location:
Centrosome.
Tissue Specificity:
Ubiquitously expressed.
Similarity:
Belongs to the TUBGCP family.
SWISS:
Q9UGJ1
Gene ID:
27229
Database links:
Entrez Gene: 27229 Human
Entrez Gene: 51885 Mouse
Omim: 609610 Human
SwissProt: Q9UGJ1 Human
SwissProt: Q9D4F8 Mouse
Unigene: 584887 Human
Unigene: 383499 Mouse
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