Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
Function:
May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.
Subunit:
Interacts with GNA12 and GNA13 through the RGS domain. Interacts with RHOA, PLXNB1 and PLXNB2. Interacts with SLC1A6 (By similarity).
Subcellular Location:
Cytoplasm. Membrane. Note=Translocated to the membrane upon stimulation.
Tissue Specificity:
Ubiquitously expressed.
Similarity:
Contains 1 DH (DBL-homology) domain.
Contains 1 PDZ (DHR) domain.
Contains 1 PH domain.
Contains 1 RGSL (RGS-like) domain.
SWISS:
O15085
Gene ID:
9826
Database links:
Entrez Gene: 9826 Human
Entrez Gene: 213498 Mouse
Entrez Gene: 78966 Rat
Omim: 605708 Human
SwissProt: O15085 Human
SwissProt: Q9ES67 Rat
Unigene: 516954 Human
Unigene: 160580 Rat
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