In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. [provided by RefSeq, Jul 2008].
Function:
Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Note=A chromosomal aberration involving GMPS is found in acute myeloid leukemias. Translocation t(3,11)(q25,q23) with MLL.
Similarity:
Contains 1 glutamine amidotransferase type-1 domain.
Contains 1 GMP-binding domain.
SWISS:
P49915
Gene ID:
8833
Database links:
Entrez Gene: 8833 Human
Entrez Gene: 229363 Mouse
Omim: 600358 Human
SwissProt: P49915 Human
SwissProt: Q3THK7 Mouse
Unigene: 591314 Human
Unigene: 331051 Mouse
Unigene: 394565 Mouse
Unigene: 441120 Mouse
|
|
