The nuclear pore complex (NPC) mediates bidirectional macromolecular traffic between the nucleus and cytoplasm in eukaryotic cells and is comprised of more than 100 different subunits. Many of the subunits belong to a family called nucleoporins (Nups), which are characterized by the presence of O-linked-N-acetylglucosamine moieties and a distinctive pentapeptide repeat (XFXFG). gp210, also known as Nup210 (nucleoporin 210kDa) or POM210, is a 1,887 amino acid single-pass type I membrane protein that localizes to both the endoplasmic reticulum and to the nucleus, specifically within the NPC. Expressed ubiquitously with highest expression in pancreas, testis, lung, ovary and liver, gp210 functions as a nucleoporin that is capable of dimerization and is essential for the assembly, fusion and structural integrity of the NPC. gp210 exists as multiple alternatively spliced isoforms and is subject to post-translational phosphorylation.
Function:
Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity.
Subunit:
Forms dimers and possibly higher-order oligomers (By similarity).
Subcellular Location:
Nucleus; nuclear pore complex. Nucleus membrane. Endoplasmic reticulum membrane.
Tissue Specificity:
Ubiquitous expression, with highest levels in lung, liver, pancreas, testis, and ovary, intermediate levels in brain, kidney, and spleen, and lowest levels in heart and skeletal muscle.
Post-translational modifications:
N-glycosylated, but not all potential glycosylation sites may be used. Contains high-mannose type oligosaccharides.
Phosphorylated at Ser-1881 in mitosis specifically; not phosphorylated in interphase.
Similarity:
Belongs to the NUP210 family.
SWISS:
Q8TEM1
Gene ID:
23225
Database links:
Entrez Gene: 23225 Human
Entrez Gene: 54563 Mouse
Entrez Gene: 58958 Rat
Omim: 607703 Human
SwissProt: Q8TEM1 Human
SwissProt: Q9QY81 Mouse
SwissProt: P11654 Rat
Unigene: 475525 Human
Unigene: 28162 Mouse
Unigene: 3189 Rat
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