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Home > Product > Antibody > Rabbit Anti-GPR124 antibody
DKFZp434C211; DKFZp434J0911; FLJ14390; G protein coupled receptor 124; G-protein coupled receptor 124; GP124_HUMAN; GPR 124; GPR124; KIAA1531; TEM 5; TEM5; Tumor endothelial marker 5; Tumor endothelial marker 5 precursor; GPCR GPR124.
Cat:
SL13515R
Species Reactivity：
Human,Mouse,Rat,(predicted: Dog,Pig,Cow,Horse,Sheep,)
Immunogen：
KLH conjugated synthetic peptide derived from human G protein coupled receptor 124:351-450/1338<Extracellular>
Format：
Liquid
Storage instructions：
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Product Overview：
Sample: Lane 1: Placenta (Mouse) Lysate at 40 ugLane 2: Lung (Mouse) Lysate at 40 ugLane 3: Large intestine (Rat) Lysate at 40 ugLane 4: Lung (Rat) Lysate at 40 ugLane 5: U2os (Human) Cell Lysate at 30 ugPrimary: Anti-GPR124 (SL13515R) at 1/1000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 36-200 kDObserved band size: 245 kD
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Unit:
Price: $
Product PDFs
Datasheet:


Tumor endothelial markers (TEMs) are abundantly expressed in the blood vessels of human solid tumors during angiogenesis and neoangiogensis. These include TEM1 (endosialin), TEM5 (G-protein coupled receptor 124) and TEM7 (plexin domain containing 1). TEMs are associated with the cell surface membrane at low levels in normal human and mouse tissues. TEM5 is a seven-pass transmembrane receptor, whereas TEM1, TEM7 and TEM8 span the membrane once. TEM5 expression is elevated during tumor angiogenesis and neoangiogenesis. TEM7 is highly expressed in tumor endothelium and neurons. Therefore, TEM5 and TEM7 may be suitable targets for the development of antiangiogenic therapies.

Function:
Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Required for normal endothelial cell sprouting and migration in the forebrain and neural tube.

Subunit:
Interacts with DLG1.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Expressed in endothelial cells (at protein level). Abundantly expressed in tumor vessels, heart, placenta, ovary, small intestine, and colon.

Similarity:
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Contains 1 GPS domain.
Contains 1 Ig-like (immunoglobulin-like) domain.
Contains 4 LRR (leucine-rich) repeats.
Contains 1 LRRCT domain.
Contains 1 LRRNT domain.

SWISS:
Q96PE1

Gene ID:
25960

Database links:

Entrez Gene: 25960 Human

Entrez Gene: 306543 Rat

Omim: 606823 Human

SwissProt: Q96PE1 Human

Unigene: 274136 Human



Picture

Sample:
Lane 1: Placenta (Mouse) Lysate at 40 ug
Lane 2: Lung (Mouse) Lysate at 40 ug
Lane 3: Large intestine (Rat) Lysate at 40 ug
Lane 4: Lung (Rat) Lysate at 40 ug
Lane 5: U2os (Human) Cell Lysate at 30 ug
Primary: Anti-GPR124 (SL13515R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 36-200 kD
Observed band size: 245 kD
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