G protein-coupled receptor 17, GPR17, also known as uracil nucleotide/cysteinyl leukotriene receptor or P2Y-like receptor (P2YL), is a 367 amino acid member of the G-protein coupled receptor 1 family of proteins. While GPR17 is expressed in kidney, heart and umbilical vein endothelial cells, it is expressed in the highest levels in the brain. Upon brain injury, the extracellular concentrations of nucleotides and cysteinyl leukotrienes (CysLTs), two families of endogenous signaling molecules, increase significantly at the site of damage. In some neurons, GPR17, a membrane receptor for uracil nucleotide and CysLTs, is upregulated as well, infiltrating the lesioned area. GPR17 is thought to play a role in mediating neuronal death, remodeling brain circuitries by microglia and initiating remyelination in damaged neurons. Two named isoforms of GPR17 exist as a result of alternative splicing events.
Function:
Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.
Subcellular Location:
Cell membrane.
Tissue Specificity:
Expressed in brain, kidney, heart and umbilical vein endothelial cells. Highest level in brain.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
SWISS:
Q13304
Gene ID:
2168
Database links:
Entrez Gene: 2168 Human
Entrez Gene: 57882 Mouse
Entrez Gene: 767613 Rat
Omim: 603071 Human
SwissProt: Q13304 Human
SwissProt: Q6NS65 Mouse
SwissProt: Q09QM4 Rat
Unigene: 46453 Human
Unigene: 688940 Human
Unigene: 391108 Mouse
Unigene: 212749 Rat
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