NOB1P is a 412 amino acid nuclear protein that is involved in proteosome biogenesis and is required for the final step in 18S rRNA maturation. NOB1P contains a PIN domain, which functions as a nuclease in nonsense-mediated mRNA decay and is required for pre-rRNA cleavage. NOB1P interacts with Rent2, which is involved in nonsense-mediated decay of mRNAs containing premature stop codons. Expressed in placenta, spleen, endothelial cells, liver and lung, NOB1P is essential for the synthesis of 40S ribosome subunits. Supression of the gene encoding NOB1P inhibits the processing of the 20S pre-rRNA to the mature 18S rRNA, therefore leading to accumulation of high levels of 20S pre-rRNA with degradation intermediates.
Function:
May play a role in mRNA degradation.
Subcellular Location:
Nucleus.
Tissue Specificity:
Detected in liver, lung, placenta, endothelial cells and spleen.
Similarity:
Belongs to the NOB1 family.
Contains 1 PINc domain.
SWISS:
Q9ULX3
Gene ID:
28987
Database links:
Entrez Gene: 28987 Human
Entrez Gene: 67619 Mouse
Entrez Gene: 291996 Rat
Omim: 613586 Human
SwissProt: Q9ULX3 Human
SwissProt: Q8BW10 Mouse
SwissProt: Q6VEU1 Rat
Unigene: 271695 Human
Unigene: 334793 Mouse
Unigene: 102586 Rat
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