Brp16 is a 256 amino acid protein encoded by a gene on human chromosome 8. Made up of nearly 146 million bases, chromosome 8 encodes about 800 genes. Translocation of portions of chromosome 8 with amplifications of the c-Myc gene are found in some leukemias and lymphomas, and typically associated with a poor prognosis. Portions of chromosome 8 have been linked to schizophrenia and bipolar disorder. Trisomy 8, also known as Warkany syndrome 2, most often results in early miscarriage but is occasionally seen in a mosaic form in surviving patients who suffer to a varying degree from a number of symptoms including retarded mental and motor development, and certain facial and developmental defects. WRN is a DNA helicase encoded by chromosome 8 and shown defective in those with the early aging disorder Werner syndrome. Chromosome 8 is also associated with Pfeiffer syndrome, congenital hypothyroidism and Waardenburg syndrome.
Similarity:
Belongs to the FAM203 family.
SWISS:
Q9BTY7
Gene ID:
51236
Database links:
Entrez Gene: 51236 Human
Entrez Gene: 728071 Human
Entrez Gene: 59053 Mouse
Entrez Gene: 315094 Rat
SwissProt: Q9BTY7 Human
SwissProt: Q8C3I8 Mouse
SwissProt: Q6AY79 Rat
Unigene: 300224 Human
Unigene: 13642 Mouse
Unigene: 17102 Rat
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