This gene encodes a sperm membrane protein that binds the zona pellucida of the egg in a species-specific manner. The encoded protein may be involved in signaling or gamete recognition. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
Function:
Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling.
Subunit:
Probably forms covalent oligomers.
Subcellular Location:
Cell membrane. Exclusively on the apical region of the sperm head.
Tissue Specificity:
In testis, primarily in haploid spermatids.
Similarity:
Contains 1 EGF-like domain.
Contains 3 MAM domains.
Contains 4 TIL (trypsin inhibitory-like) domains.
Contains 5 VWFC domains.
Contains 4 VWFD domains.
SWISS:
Q9Y493
Gene ID:
7455
Database links:
Entrez Gene: 7455 Human
Entrez Gene: 22635 Mouse
Omim: 602372 Human
SwissProt: Q9Y493 Human
SwissProt: O88799 Mouse
Unigene: 307004 Human
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