Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.
Function:
Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity).
Subunit:
Monomer
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Widely expressed.
Similarity:
Belongs to the NADP-dependent oxidoreductase L4BD family.
SWISS:
Q8N8N7
Gene ID:
145482
Database links:
Entrez Gene: 145482 Human
GenBank: NP_001139626.1 Human
Omim: 608642 Human
SwissProt: Q8N8N7 Human
Unigene: 632344 Human
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