Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZBTB4 (zinc finger and BTB domain containing 4), also known as KAISO-L1 (KAISO-like zinc finger protein 1), is a 1,013 amino acid nuclear protein that is involved in transcriptional regulation. ZBTB4 contains one BTB (POZ) domain, six C2H2-type zinc fingers and is phosphorylated and downregulated by HIPK2. The gene encoding ZBTB4 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes.
Function:
May be involved in transcriptional regulation.
Subunit:
Interacts with HIPK2.
Subcellular Location:
Nucleus.
Post-translational modifications:
Phosphorylated by HIPK2. This phosphorylation reduces stability and triggers ZBTB4 protein degradation in response to DNA damage.
Similarity:
Contains 1 BTB (POZ) domain.
Contains 6 C2H2-type zinc fingers.
SWISS:
Q9P1Z0
Gene ID:
57659
Database links:
Entrez Gene: 57659 Human
Entrez Gene: 75580 Mouse
Entrez Gene: 287441 Rat
Omim: 612308 Human
SwissProt: Q9P1Z0 Human
Unigene: 35096 Human
|
|
