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Rabbit Anti-ZBTB43 antibody
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. Zinc finger and BTB domain-containing protein 43 (ZBTB43), also known as ZNF297B or ZBTB22B, is a 467 amino acid member of the Krüppel C2H2-type zinc-finger protein family. Localized to the nucleus, ZBTB43 contains a BTB domain, also known as a POZ domain, which inhibits DNA binding and mediates homotypic and heterotypic dimerization. Characteristics of the BTB domain and the interaction of ZBTB43 with BDP1 suggest that ZBTB43 functions as a transcription regulator.
Function:
May be involved in transcriptional regulation.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 1 BTB (POZ) domain.
Contains 3 C2H2-type zinc fingers.
SWISS:
O43298
Gene ID:
23099
Database links:
Entrez Gene: 23099 Human
Entrez Gene: 71834 Mouse
Entrez Gene: 311872 Rat
SwissProt: O43298 Human
SwissProt: Q9DAI4 Mouse
SwissProt: Q5PQT4 Rat
Unigene: 355581 Human
Unigene: 44186 Mouse
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