Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. Zinc finger and BTB domain-containing protein 48 (ZBTB48), also known as Kruppel-related zinc finger protein 3 or HKR3, is a 688 amino acid member of the Krüppel C2H2-type zinc-finger protein family. Localized to the nucleus, ZBTB48 is expressed in the adrenal gland and neuroblastoma cell lines. ZBTB48 contains a BTB domain, also known as a POZ domain, which inhibits DNA binding and mediates homotypic and heterotypic dimerization. Characteristics of the BTB domain suggest that ZBTB48 functions as a transcription regulator.
Function:
Binds to and regulates the J and/or S elements in MHC II promoter.
Subcellular Location:
Nucleus.
Tissue Specificity:
Detected in adrenal gland and neuroblastoma.
Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 1 BTB (POZ) domain.
Contains 11 C2H2-type zinc fingers.
SWISS:
P10074
Gene ID:
3104
Database links:
Entrez Gene: 3104 Human
Entrez Gene: 100090 Mouse
Omim: 165270 Human
SwissProt: P10074 Human
SwissProt: Q1H9T6 Mouse
Unigene: 502330 Human
Unigene: 24661 Mouse
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