Rabbit Anti-C9orf95/NRK antibody

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bA235O14.2; C9orf95; Chromosome 9 open reading frame 95; FLJ20559; Nicotinamide riboside kinase 1; Nicotinic acid riboside kinase 1; NmR-K 1; NRK 1; NRK1; NRK1_HUMAN; Ribosylnicotinamide kinase 1; Ribosylnicotinic acid kinase 1; RNK 1; RP11-235O14.2.

Cat:

SL15349R

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human C9orf95:1-100/199

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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Nicotinamide adenine dinucleotide (NAD+) is an essential cofactor involved in fundamental processes in cell metabolism. NRK1 (Nicotinamide riboside kinase 1), also known as Ribosylnicotinamide kinase 1, is a 199 amino acid enzyme is involved in the synthesis of NAD+ through nicotinamide mononucleotide using nicotinamide riboside as the precursor. Nicotinamide riboside has been idenitifed as a nutrient in milk, suggesting that it is a useful compound for elevating the NAD+ levels in humans. NRK1 also phosphorylates the anti-cancer drugs tiazofurin and 3-deazaguanosine, which converts them into toxic NAD+ analogs and leads to the inhibition of guanine nucleotide biosynthesis. There are two isoforms of NRK1 that are produced as a result of alternative splicing events.

Function:
Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). The enzyme also phosphorylates the antitumor drugs tiazofurin and 3-deazaguanosine.

Subunit:
Monomer.

Similarity:
Belongs to the uridine kinase family. NRK subfamily.

SWISS:
Q9NWW6

Gene ID:
54981

Database links:

Entrez Gene: 54981 Human

Entrez Gene: 499330 Rat

Omim: 608704 Human

SwissProt: Q9NWW6 Human

SwissProt: Q6AY91 Rat

Unigene: 494186 Human

Unigene: 19716 Rat

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