The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid taste receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Function:
Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.
Subunit:
Forms heterodimers with TAS1R3.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Similarity:
Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.
SWISS:
Q7RTX1
Gene ID:
80835
Database links:
Entrez Gene: 80835 Human
Entrez Gene: 110326 Mouse
Entrez Gene: 29407 Rat
Omim: 606225 Human
SwissProt: Q7RTX1 Human
SwissProt: Q99PG6 Mouse
SwissProt: Q9Z0R8 Rat
Unigene: 124574 Human
Unigene: 29232 Mouse
Unigene: 92309 Rat
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