G protein-coupled receptors play a role in many different stimulus-response pathways. G protein-coupled receptors mediate extracellular signals into intracellular signals (G protein activation). They respond to a wide variety of signaling molecules, including hormones, neurotransmitters and other proteins and peptides. GASP-2 (G protein-coupled receptor associated sorting protein 2), also known as GPRASP2, is an 838 amino acid protein that regulates a number of G-protein coupled receptors, such as CT-R (calcitonin receptor) and mAChR M1 (muscarinic acetylcholine receptor M1), through interactions with their cytoplasmic tails. Expressed primarily in brain, GASP-2 is a member of the GPRASP family and forms a complex with Huntingtin, with which it is thought to influence receptor trafficking.
Function:
May play a role in regulation of a variety of G-protein coupled receptors.
Subunit:
Interacts with cytoplasmic tails of a variety of G-protein coupled receptors such as muscarinic acetylcholine receptor M1/CHRM1 and calcitonin receptor/CALCR.
Subcellular Location:
Cytoplasmic
Tissue Specificity:
Expressed in the brain.
Similarity:
Belongs to the GPRASP family.
SWISS:
Q96D09
Gene ID:
114928
Database links:
Entrez Gene: 114928 Human
Entrez Gene: 245607 Mouse
GenBank: NP_001004051 Human
SwissProt: Q96D09 Human
SwissProt: Q8BUY8 Mouse
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