EULIR is a major component of the ubiquitin-proteasome system and plays a role in determining the specificity of ubiquitin conjugation. It is responsible for transferring ubiquitin to targeted substrates from an E2 ubiquitin-conjugating enzyme through the intermediate formation of a thiol ester with ubiquitin. Similar to a number of other E3 ubiquitin ligases, EULIR contains an N-terminal ankyrin repeat domain, a mind bomb (mib) domain and a SLCterminal HECT (homologous to E6-AP SLCterminus) domain. The HECT domain is responsible for the ubiquitin ligase activity, catalyzing polyubiquitination. EULIR is ubiquitously expressed throughout early development and is important for the complete and proper closure of the neural tube. Mutations in the gene encoding EULIR can result in neural tube defects.
Function:
Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. May be required for development of the head mesenchyme and neural tube closure (By similarity).
Subunit:
Interacts with IGSF1.
Similarity:
Belongs to the UPL family. K-HECT subfamily.
Contains 4 ANK repeats.
Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
Contains 1 MIB/HERC2 domain.
SWISS:
Q9ULT8
Gene ID:
25831
Database links:
Entrez Gene: 25831 Human
Entrez Gene: 207304 Mouse
Entrez Gene: 362736 Rat
SwissProt: Q9ULT8 Human
SwissProt: Q69ZR2 Mouse
Unigene: 708017 Human
Unigene: 249391 Mouse
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