HERC1 is a stimulates guanine nucleotide exchange on ARF1 and Rab proteins. This protein may be involved in membrane transport processes.
Function:
Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Subunit:
Interacts with TSC2; interaction is inhibited by TSC1. Interacts with PKM, ARF1 and ARF6. Forms a ternary complex with clathrin heavy chain (CLTC) and HSPA1A.
Subcellular Location:
Membrane; Peripheral membrane protein. Cytoplasm, cytosol. Golgi apparatus. Note=Recruited onto actin-rich surface protrusions.
Tissue Specificity:
Widely expressed.
Similarity:
Contains 1 B30.2/SPRY domain.
Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
Contains 14 RCC1 repeats.
Contains 11 WD repeats.
SWISS:
Q15751
Gene ID:
8925
Database links:
Entrez Gene: 538029 Cow
Entrez Gene: 8925 Human
Entrez Gene: 235439 Mouse
Entrez Gene: 100153537 Pig
Entrez Gene: 315771 Rat
Omim: 605109 Human
SwissProt: Q15751 Human
Unigene: 210385 Human
Unigene: 244179 Mouse
Unigene: 26488 Rat
|
|
