HERC3 is a member the HERC ubiquitin ligase family. The encoded protein is located in the cytosol and binds ubiquitin via a HECT domain. Mutations in this gene have been associated with colorectal and gastric carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity).
Subcellular Location:
Cytoplasm. Cytoplasmic vesicle. Note=Also found in vesicular-like structures.
Post-translational modifications:
Ubiquitinated; which promotes degradation by the proteasome.
Similarity:
Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
Contains 7 RCC1 repeats.
SWISS:
Q15034
Gene ID:
8916
Database links:
Entrez Gene: 8916 Human
Entrez Gene: 73998 Mouse
Entrez Gene: 362377 Rat
Omim: 605200 Human
SwissProt: Q15034 Human
Unigene: 35804 Human
Unigene: 191892 Mouse
Unigene: 203362 Rat
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